Introduction of Reduced Glutathione

Reduced glutathione is a tri-peptide molecule consisting of glutamate, cysteine and glycine.

As a matter of fact, it is the most abundant low-molecular-weight thiol-containing molecule in the cell.

Wide existence in nature

Reduced glutathione exists in mammals, plants and microorganism extensively. It exists in human body with a balance between
its reduced form (GSH), and its oxidized form (GSSG) – a disulfide. In tissue, the ratio of GSH vs. GSSG is normally 99 to 1, but in
blood plasma the ratio is about 1 to 6.

Introduction of Lutasun

The active ingredient of Lutasun is reduced glutathione. Glutathione has been marketed since 1970s and used in the treatment of liver diseases and detoxification. Mainly four types of formulations of GSH are currently used in clinical settings, including lyophilized powder for injection, tablet, powder and eye drop.
LUTASUN in China
Lyophilized powder for injection of GSH was first imported to China in 1986. Since then, the market demand for Glutathione has been increasing steadily. In 1996, YaoPharma became the first company to develop Glutathione in China, and was able to obtain the approval of CFDA within 3 years. Today, Glutathione has been used in thousands of hospitals across China, and millions of patients benefit from the protection of Glutathione each year.

Formulation & Dosage

Lyophilized powder for injection

Strengths: 300mg, 600mg, 1.2g Administration route: (1) Intravenous drip: dissolve 600mg in 4ml water for injection, or dissolve 1.2g in 7ml water for injection. Add the solution into 100ml, 250ml, 500ml physiologic saline or 5% glucose solution for intravenous infusion respectively. (2) Intramuscular injection: dissolve 600mg in 4 ml water for injection then administer.



Strengths: 100mg, 200mg Indication: Liver protection in the case of chronic hepatitis B. Usage and Administration: The usual dose for adults is 400 mg once orally, three times a day. The course of treatment is 12 weeks.