Chemotherapy on Tumor

  • The therapeutic effects of GSH on liver damage caused by chemotherapy

    GSH is effective at preventing or treating liver damage caused by chemotherapy drugs.

    Clinical data of 102 patients receiving chemotherapy were analyzed retrospectively. 17 patients was divided into treatment group with 9 males and 8 females, and with the average age of 37±s 18a. GSH (0.6~1.2g, i.v.gtt, qd×10~14d) was administrated when liver dysfunction occurred. 46 patients were divided into prevention group with 28 males and 18 females, and with the average age of 39±13a. Patients were administered with GSH 2 days before chemotherapy, with same administration method as the treatment group. 39 patients were divided into the control group with 24 males and 15 females, and with the average of 38±11a. Patients received chemotherapy drugs with no GSH.

    Reference: Mao Yaosheng. Therapeutic effect of reduced glutathione hormone on damaged liver after trauma [J]. Chinese Journal of Traumatology, 2002, 18 (5) : 287-289

  • Neuroprotective Effect of Reduced Glutathione

    GSH is a promising and effective new drug for the prevention of CDDP-induced neuropathy.

    50 patients with advanced gastric cancer treated with a weekly CDDP-based regimen were included. In GSH arm (25 patients), GSH was given at a dose of 1.5g/m2 in 100mL of normal saline solution before CDDP administration, and at a dose of 600mg on days 2 to 5. Normal saline solution was administered to placebo-randomized patients (25 patients).

    Reference : Stefano Cascinu, et al. Neuroprotective Effect of Reduced Glutathione on Cisplatin – Based Chemotherapy in Advanced Gastric Cancer: A Randomized Double – Blind Placebo –Controlled Trial, Journal of Clinical Oncology, Vol 13, No 1 (January), 1995: pp 26-32