The liver is the largest gland in the body and performs a large number of tasks that impact all body systems. The liver lies in the abdominal cavity, in contact with diaphragm. Its mass consists of several lobes. Every 2 minutes, all blood in the body flow through the liver. Many important changes will take place when the blood flows through the liver. The major functions of the liver include: secretion of bile, substance metabolism and detoxification. The liver dysfunction has bad influences on its functions. Liver disease is a broad term describing any number of diseases affecting the liver. The following charts show the relationships among different types of liver diseases.